The evening is jam-packed full of celebrity guest appearances, including a celeb version of Gogglebox with stars including Olly Murs and Niall Horan.
There's also a special Last Leg, an edition of Humans, and a mini-episode of 90s classic Streetmate mixed with First Dates.
Loads of famous faces are lending a hand too with Broadchurch stars Olivia Colman and David Tennant going head to head, Britney Spears, a special sketch featuring Jon Hamm, Matthew McConaughey and Eva Longoria, and much, much more.
Stand Up To Cancer, Channel 4, 7pm
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