The usually private French actress released a statement via Instagram shutting down the idea she played any part in Angelina's decision to file for divorce from Brad after a two-year marriage and decade long relationship.
Marion met Brad while they filmed upcoming drama Allied in London earlier this year.
Marion wrote: "This is going to be my first and only reaction to the whirlwind news that broke 24 hours ago and that I was swept up into. I am not used to commenting on things like this nor taking them seriously but as this situation is spiralling and affecting people I love, I have to speak up."
She went on to point out she's happily married… and announced her second pregnancy.
"Many years ago, I met the man of my life, father of our son and of the baby we are expecting. He is my love, my best friend, the only one that I need," she wrote, before dismissing the idea she is feeling "devastated" over the situation.
"I am very well thank you."
She concluded with well wishes to Brangelina in this tough time: "I do very much wish that Angelina and Brad, both whom I deeply respect, will find peace in this very tumultuous moment."
This is going to be my first and only reaction to the whirlwind news that broke 24 hours ago and that I was swept up into. I am not used to commenting on things like this nor taking them seriously but as this situation is spiraling and affecting people I love, I have to speak up. Firstly, many years ago, I met the man of my life, father of our son and of the baby we are expecting. He is my love, my best friend, the only one that I need. Secondly to those who have indicated that I am devastated, I am very well thank you. This crafted conversation isn't distressing. And to all the media and the haters who are quick to pass judgment, I sincerely wish you a swift recovery. Finally, I do very much wish that Angelina and Brad, both whom I deeply respect, will find peace in this very tumultuous moment. With all my love Marion Ceci sera la première et seule réaction que j'aurai concernant la déferlante inouïe qui à commencé il y a de ça 24 heures et à laquelle je suis mêlée malgré moi. Je n'ai pas pour habitude de commenter ni de prendre au sérieux le tas d'absurdités déversées à mon sujet mais la situation prenant une telle tournure et affectant des gens que j'aime, je me dois de m'exprimer. Pour commencer, j'ai rencontré il y a quelques années l'homme de ma vie , le père de notre fils et du bébé que nous attendons aujourd'hui. Il est mon amour, mon meilleur ami et le seul homme dont j'ai besoin. Ensuite, à ceux qui me prétendent dévastée, je vais très bien merci. Ce genre d'inventions aberrantes ne m'affecte en aucun cas. Et pour finir, à la "presse", à tous les haters, trolls et consorts qui ont le jugement si rapide je vous souhaite sincèrement... un prompt rétablissement. Ceci dit et un peu plus sérieusement, je souhaite à Angelina et Brad, deux personnes pour qui j'ai un profond respect, de trouver la paix dans ce moment tumultueux. Avec tout mon amour. Marion
The showbiz world was rocked when it emerged this week that Angelina, 41, had filed divorce papers against Brad, 52, seeking to end their 12-year relationship.
Legal documents show irreconcilable differences listed as the cause but, as neither Ange nor Brad has given a reason for the break-up, the rumour mill has been mounting.
As well as dragging Marion into the mix, other unconfirmed speculation has suggested Angelina was unhappy about Brad's attitude to parenting.
The only statements Brangelina have released so far have been very brief and simply to confirm the split.
Angelina's attorney said on her behalf: "This decision was made for the health of the family. She will not be commenting at this time, and asks that the family be given their privacy during this difficult time."
Brad said: "I am very saddened by this, but what matters most now is the well-being of our kids."
They met on the set of action movie Mr and Mrs Smith. Angelina once said the Jolie-Pitt kids could look back at the movie and see the moment their parents fell in love, which sparked controversy as Brad was married to Jennifer Aniston at the time.
After a 2012 engagement, they wed at their French chateau in 2014.