Alongside the main music stages, the charity had its very own sandy beach enclosure at Seaclose Park, where visitors could try out some Bear Grylls challenges, have their face painted, and watch live music.
Stand Up To Cancer was the official charity partner of this year's festival, and enlisted the help of MIC's JP to kick off festivities on Friday, 10 June.
JP showed off his skills by getting stuck into the Bear Grylls Survival Challenge taking place at the beach. As well as weight lifting, there was a tug of rope.
He tweeted: "Having such a class time @IsleOfWightFest with all the @SU2C team. #standuptocancer #festival #summer."
And it appears being on the beautiful Isle of Wight really made an impression on JP, as he later told fans: "I think I'm in paradise, buying a house in Isle of Wight is on my list!!!! Better save those penny's!!! (sic)"
As well as hosting the beach area, the charity was selling masks with David Bowie's face on them ahead of a tribute on Saturday afternoon.
Festival goers were encouraged to wear their masks during the official Bowie tribute on the main stage, which saw Andrea Corr and Gary Kemp perform a cover of 'Starman', and footage from Bowie's last-ever UK gig, at Isle of Wight Festival 2004, was played.