Actress Amber has filed for divorce at Los Angeles Superior County citing "irreconcilable differences", just 15 months after they wed in a secret ceremony in California.
According to TMZ, Johnny has asked for spousal support to be denied.
Neither Johnny nor Amber has publicly commented yet.
Johnny, 52, and Amber, 30, met on the set of 2011 movie The Rum Diary and began dating the following year, after Johnny split from long-time love Vanessa Paradis, the mother of his two children: model Lily Rose, 16, and 13-year-old Jack.
The divorce news comes just a month after they were told to publicly apologise for smuggling two dogs into Australia without going through the proper channels. Amber had brought their pups Pistol and Boo to the country while Johnny was filming the latest Pirates of the Caribbean movie, but failed to declare them.
They released a video apology.