The special episode will see Made In Chelsea's Spencer and former EastEnders actor Larry join regular Loose Women Andrea McLean and Linda Robson on the panel debating the hot topics of the day while sharing personal stories.
Meanwhile, Joe Swash will also appear on the special as the show's roving backstage reporter.
Spencer said: "I've been referred to as a 'Loose Man' many times over the course of my life but now for the first time I can be proud of it! Joining the lovely Loose Women team is an exciting time for me - I can't wait to get started!"
Meanwhile, Larry commented: "I'm really looking forward to getting on the panel - I'd like to think I might make a bit of a difference, maybe learn a little!"
The first episode of Loose Women & Men aired in January, and another special, Loose Women & Kids recently aired with Katie Price's children Princess and Junior as two of the guests on the show.
Loose Women editor, Sally Shelford, added: "All three Loose Men have been brilliant guests on the show and now it's their turn to take their place at the desk. Expect lots of laughs and a few revelations along the way."
Loose Women & Men - Friday 6th May at 12.30pm on ITV
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