The model and reality TV star, 32, told her 414,000 Twitter fans on Sunday (17 April) that she was leaving because she could no longer cope with trolls.
Her decision also came after an exchange online with ex-husband Jamie O'Hara.
After a series of comments from footballer Jamie, Celebrity Big Brother star Danielle posted the following message on Twitter.
She said: "Am sorry to all my fans but am going to have to leave social media as I will not be abused lies about.. I just want to be a mother."
She added: "Thanks to all my fans for support I will be back but the trolls and my ex have finally warn me down and I can't cope X."
Her supporters rallied around her, with one responding: "Don't give people the satisfaction of letting them get to you and letting them know they have upset you."
Another said: "You should ignore the haters. Giving in to them means they win. #StayStrong."
Danielle's decision came just a few hours after Fulham footballer Jamie - the father of her three children Archie, Harry and George - posted a series of tweets directed at her.
Standing up for myself finally because of two years of hell ive endured as a father trying to rebuild my career and life after a divorce— Jamie Ohara (@Mrjamieohara1) April 17, 2016
The 29-year-old, who allegedly cheated on Danielle causing their relationship to breakdown, claims he's been degraded by his ex-wife.
He says: "Was I not degraded for two years while my name was dragged through the mud in various papers that my ex got paid to do."
Clearly angry, he continued: "Im making this statement because I will not tolerate being called a liar, I made my mistakes but ive not said a word for two years.
"Standing up for myself finally because of two years of hell ive endured as a father trying to rebuild my career and life after a divorce."
Jamie had backing from his own followers, with one saying: "We all make mistakes but we shouldn't be punished for them continuously." Another said: "You don't need to justify yourself to anyone Jamie, it's a long game so take the moral high ground for the boys sake."
He also accuses Danielle of running up £6,000 on his credit card for a Dubai holiday and refusing to leave the £750,000 house they lived in together.
The spat first began after Danielle's appearance on Loose Women this week when she discussed her new man Michael O'Neill spending time with her boys.
She admitted she's been called a "disgrace" for posting a photo of Michael cuddling one of her sons in bed.
Danielle and Jamie split in 2014. She recently got engaged to electrician Michael.
He popped the question on a Valentine's Day trip to London after a nine-month whirlwind romance.
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