The couple – who have two young sons together - announced via a post on Laurence's official Facebook page that they're separating after nearly nine years of marriage.
It read: "Laurence Fox and Billie Piper have separated. No third parties involved. For the sake of our family we request and appeal for space and privacy at this time."
They have two children: Winston, seven, and Eugene, three.
Billie, 33, and Lewis actor Laurence, 37, married in December 2007 in West Sussex. They initially met while starring together in a play called Treats.
Former Doctor Who and Secret Diary of a Call Girl star Billie was previously married to DJ Chris Evans from 2001 until 2004.
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