Sophie will leave on screen in a few weeks' time, as the Gloved Hand Killer storyline will reach an explosive climax.
She told the Daily Star: "I'm really sad to be leaving Hollyoaks, it's been such a huge part of my life for so long."
Lindsey's exit comes as she also announced her split from husband Graeme Rooney. They married last July but split earlier this year.
"It's also a huge time of change for me personally as, very sadly, my husband and I separated a little while ago," she told the newspaper.
Sophie, who said that she will "always care for him deeply", said the breakdown of her relationship had been "difficult".
Fans of the soap will know that Sophie's character Lindsey has claimed the lives of seven victims under the alias of the Gloved Hand Killer while working at Dee Valley Hospital.
Soap bosses are currently keeping details of her exit under wraps but she has already filmed her final scenes.
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