The actress and wife of Robbie Williams will take a seat on the ITV daytime show alongside Ruth Langsford, Gloria Hunniford and Linda Robson on Thursday, 10 March.
Ayda said: "I'm delighted to be joining Loose Women as a guest panellist for the day - I had a really fun time last week as a guest and now I'm looking forward to getting stuck into those topics with the ladies".
The 36-year-old was a guest on the show last week, where Robbie joined her backstage for support. It marked her first ever UK TV appearance.
Loose Women editor Sally Shelford said: "When Ayda joined us as a guest last week we knew straight away she was everything we hope for in a Loose Woman - she was funny, frank, honest and absolutely willing to share a few secrets on her other half!
"After sharing an exclusive video of Robbie having his back waxed, she is a comic genius in her own right and we can't wait to see what she has in store for us on Thursday."
Ayda and Robbie have been married since 2010 and have two children: daughter Teddy, born in 2012, and son Charlton, who arrived in 2014.