The American music producer's exit will be seen on tonight's episode of the Channel 5 show, along with the reactions of his fellow housemates, who were gathered together in the living area for a message from Big Brother.
They were told: "This is Big Brother. David has left the Big Brother house for medical reasons. David wanted to let you all know that he loves you and he is sorry but he was too sick to continue."
Jeremy McConnell and John Partridge both shouted out that they loved David, prompting all the housemates to join in, sending their well wishes to the US star.
(Watch their reactions to David's departure here.)
The nature of David's illness has not been revealed but CBB viewers knew he had been unwell recently, as he has been shown sleeping in a separate part of the house to get some rest.
Just before leaving, he took Jeremy to one side to offer some words of advice about the situation with Stephanie Davis. The two housemates have kissed despite Stephanie having a boyfriend in the outside world.
David warned Jeremy to think about his reputation and also how Stephanie's boyfriend would be feeling, and also pointed out Jez could have plenty of girls so he didn't need to chase after Steph.
Jeremy replied: "I like HER though. I'm not going to for the sake of the situation, I'm going to be the bigger person to the best of my ability. I'm going to be the bigger person and walk away, that's what I'm going to do. You don't have to tell me."
David's exit airs on tonight's CBB at 9pm on Channel 5.
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