Celine announced the sad news in a statement on her website, explaining that Rene died in their Las Vegas home.
The statement read:
"René Angélil, 73, passed away this morning at his home in Las Vegas after a long and courageous battle against cancer. The family requests that their privacy be respected at the moment; more details will be provided at a later time."
Celine and Rene married in 1994. He was Celine's former manager and the couple shared three children, René-Charles, 14, and 5-year-old twins Nelson and Eddy.
He is also father to Anne-Marie, Patrick and Jean-Pierre from previous marriages.
Rene, who was first diagnosed with throat cancer in 2000, discovered singing sensation Celine when she was just 12 years old.