The British band, who have just released their seventh album, A Head Full of Dreams, made the announcement via Twitter.
Frontman Chris Martin has said he was "excited and honoured and thrilled" to be headlining the event, which takes lace in February next year.
In a promotional video, Chris added: "It's going to be wonderful and I hope we see you there. This is the greatest moment in our band's life. We are going to give it everything we have."
Coldplay also confirmed they will have a "special guest" but are yet to confirm who.
Super Bowl, which will celebrate its 50th anniversary next year, is a popular football extravaganza among US audiences. This year's viewing figures showed the sporting event was watched by a staggering 114 million people.
This year, Katy Perry was the headline act at the annual sporting game. She brought out Lenny Kravitz and Missy Elliott as her special guests and her stage performance was full of colourful costumes, moving scenery, an animatronic tiger and even dancing sharks!
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