Karren talked about Lord Alan Sugar's show at the Cosmopolitan Ultimate Women Awards 2015 with Baileys on Wednesday (2 December).
When asked what she thinks about Selina Waterman-Smith publicly slamming the show, Karren simply quipped: "Who?"
She continued: "I don't know, I have nothing to say."
The show reaches its penultimate episode next week and Karren - who won an award for Ultimate Businesswoman - said she's enjoyed filming it.
"I love doing the show, I love working with Alan, and Claude has been a great addition," Karren told Reveal. "I would seriously miss it if I wasn't doing it."
It's been announced that Claude Littner will return for the all-important Interview stage, but Karren doesn't think it's a job for her anymore.
"I did the interviews for around two or three years but now I just do the main show," she said. "I don't do the interviews because I think it's quite difficult when you've been following the candidates around for a long time and then you look at their business plans, it's a bit awkward.
"Also, at the time the interview stage was filmed, I was interviewing for a new manager, so I couldn't have physically been able to do it."
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