The Keeping Up With The Kardashians star made the admission to a fan on Twitter while chatting with followers last night.
She tweeted: "Hands down worst year of my life lol."
Of course, she was no doubt referring mainly to estranged husband Lamar Odom's ongoing battle to regain his health after being found unresponsive at a Nevada brothel in October.
Khloe, 31, rushed to Lamar's side when he was hospitalised in Las Vegas, and stayed with him while he remained in a coma for several days. As their divorce has not been finalised, she was legally responsible for making his medical decisions.
Now, Lamar is being treated at a facility in Los Angeles where he is learning to walk again and feed himself and getting round the clock care. Khloe has said it could take more than a year before he gets back to where he was before the collapse.
As well as the stress of caring for her estranged husband, Khloe has also been battling a health issue of her own, after contracting a staph infection this month. It meant postponing several promotional duties for new book, Strong Looks Better Naked.
Khloe also had a difficult start to the year when stepfather Bruce Jenner announced that he was transitioning into a woman named Caitlyn.
Both Khloe and Caitlyn have acknowledged that Khloe struggled with the transition the most out of Caitlyn's children, with Caitlyn saying: "You would think out of all of the kids, Khloe was, the most fun, open-minded, 'yeah let's go party.' That's not the case with Khloe. She's had the toughest time with it, because she's had a lot of losses in her life. She lost her father at a young age. He died suddenly, cancer. And Lamar had his issues.
"She feels like this massive, 'My whole life's falling apart. It's my dad.' And I'm trying to explain that I can't argue that point, but I'm not going anywhere, I'm still going to be there for you."
Khloe, however, was 100 per cent supportive of Caitlyn from the moment the transition was made public, describing her as a "hero" and saying she's happy to see Caitlyn so happy and loving life.
Why is Khloe famous?
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