The girls are due to Japan to promote their new studio album Get Weird, but Jesy is too ill to travel with them.
Jesy announced via Twitter this afternoon (24 November): "Hey guys unfortunately I have a bloody horrid ear infection that is not allowing me to fly and see you beautiful Japanese mixers.
"I am so gutted that I'm not gonna be able to come over and see you guys again. I love you all very much & I can't wait to see you again soon."
Leigh-Anne Pinnock, Perrie Edwards and Jade Thirlwall will now jet off to Japan as a trio.
Posting a photo of themselves on the plane, the girls said in a message posted via Instagram: "We are gutted that our beautiful Jesminda won't be in Japan with us BUT we wouldn't miss this trip for the world! We are so excited to see our Japanese Mixers! See you soon! Leigh, Jade & Pez x PS. Get well soon Jesy."
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