The actor and presenter has been at the helm of the BBC Two panel show for 13 years and has presided over more than 180 episodes, but today it was announced that the new series will be his last.
"For 13 years I had one of the best jobs on television. Behind the camera, squadrons of quite extraordinarily brilliant researchers, programme makers and uniquely curious (in both senses of the word) people making that job so much easier," he said.
"In front of the camera, generations of lively minds and above all, of course, the wonder of nature that is Alan Davies. After passing the alphabetical halfway mark I thought it time to move on, but I will never cease to be grateful to John Lloyd for devising QI and for everyone else for making it such fun."
Stephen was initially cast as a team captain opposite Alan Davies. He agreed to step into the host's shoes for the pilot when Michael Palin had to pull out... and remained in the seat ever since.
He will be placed by Sandi Toksvig OBE.
Sandi said: "QI is my favourite television programme both to watch and to be on, so this is absolutely my dream job. (My Nordic background also makes me keen to spend time with the Elves.)
"Stephen has been utterly brilliant with the first half of the alphabet. Now I look forward to picking up the baton, mixing my metaphors and sailing towards the Land of Nod (ie Z). Who knows what lies ahead? It should all be quite interesting."
The last series of QI starring Stephen Fry begins on BBC Two at 10pm on Friday 16 October.