The music mogul spoke to The Sun about Zayn, who dramatically quit One Direction in March to pursue life as a normal 22-year-old. Only to then sign his own record deal and plan a solo career.
Since then, he's hit the headlines a few times thanks to his Twitter account, becoming embroiled in feuds with Naughty Boy and Calvin Harris, as well as raising eyebrows with a Little Mix versus Fifth Harmony tweet, just days after he split from Little Mix finacee Perrie Edwards.
Now, music mogul Simon has offered his advice.
He told The Sun: "I don't like this Twitter stuff. You are always going to regret what you say on Twitter.
"He needs to get a sense of perspective back, which is he had a great opportunity, for whatever reason he didn't want to do it anymore, so maybe keep quiet for a while, make a great record and enjoy life."
Zayn signed a solo deal with RCA Records in July, saying at the time: "I guess I never explained why I left [One Direction]. It was for this moment, to be given the opportunity to show you who I really am."
Meanwhile, One Direction's remaining members – Niall Horan, Louis Tomlinson, Liam Payne and Harry Styles – will be taking a hiatus next year, following the release of their fifth album.
They have, however, promised fans they will reunite.