Mario, who joined the reality show in 2011, has decided to bow out of the show after four years.
Mario told The Sun: "I have had a great time on TOWIE and relished the many opportunities the show has given me but after 14 series, I feel it is time to move on and explore something new."
In May, Mario got suspended for "flouting ITV rules" by promoting slimming pills on social media.
As a result he did not join the cast in Marbella for the filming of two-part special The Only Way Is Marbs, but joined them later on in the series when they were back in Essex.
He was also temporarily suspended last year, with TOWIE producers confirming he was taking time out to address "personal issues", during which Mario revealed he had "gone off the rails" following an excessive partying stint.
Mario's exit comes as he and Emma McVey were embroiled in a war of words via Twitter following their rumoured split.
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