The actress - who plays Penny in the hit comedy series - was accompanied by husband Ryan Sweeting to the glamorous, star-studded ceremony on Tuesday evening (2 June).
Kaley, 29, was honoured with the 'Comedy Actress of the Year' title thanks to her Big Bang Theory performance and movies including The Wedding Ringer.
She was presented her award by Alan Carr.
Kaley, who was sporting her newly-dyed pink hair and matching eyebrows, looked beautiful in a black dress with an embellished back. (Though, when does she not look beautiful?!.
After accepting her award, she said: "Tonight was amazing! Thank you #glamourawards for the honour! And a huge thanks to everyone involved."
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