The Keeping Up With The Kardashians star was among those sending messages to Scott on Tuesday, 26 May to mark his 32nd birthday.
Scott dates Khloe's older sister Kourtney.
Khloe, who is currently in Dubai on business, shared a collage of images to Instagram showing herself and Scott, alongside a sweet message
"I can't believe I have spent the last, what it seems like 100 birthdays with you. You have been such a blessing to our family and at times, such a headache but I couldn't imagine life without you as my brother. I love you Lord!!! Bible, you are a pretty cool brother! #TheLordAndTheLady."
Meanwhile, sister Kim added: "So many years, so many memories! So happy to have you as a brother and friend! I love you!!!!!"
Scott celebrated his birthday with Kourtney in Las Vegas over the weekend. They left the kids - Mason, five, Penelope, two, and six-month-old Reign - at home to party up a storm in Sin City on Saturday evening.
"Happy happy birthday to my handsome, hilarious, sweet soul mate," said Kourtney yesterday.
All you need to know about Kourtney Kardashian in just one minute:
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