The Brit actress, who has been enjoying fame in the US, heard the bad news this week that One Big Happy is not being renewed.
Despite this devastating blow, Kelly still painted a big smile on her face to pose for a selfie with fellow TV actress Liz Hurley while in the romantic Italian city.
And they both looks GORGEOUS!
NBC executives confirmed that Kelly's series One Big Happy has been stopped after just six episodes due to poor ratings.
Less than three million viewers tuned in to see Kelly's character Prudence marry her lover's lesbian best friend.
Elisha Cuthbert, star of 24, also appears alongside 90210's Nick Zano.
Kelly - who is dating French model Jeremy Parisi - confirmed the news on Twitter when she said: "Going to miss my @NBCOneBigHappy Family a lot but so grateful for the experience and the most amazing opportunities it has brought to me."
She later added: "The most incredible, creatively challenging and most rewarding job I have ever had. I will miss this Family so much. We Laughed, Cried and ate a lot of Cheese together over the past 18months.
"Friendships for Life not just a Season. I wish you all the best and can't wait to see you go on and Shine in other projects and your own individual ones. I learnt so much from everyone of you. Love you with all my heart. Going off to cry now."
But her megawatt smile in Venice suggests you can't keep a good woman down.
The sitcom was perceived to be 35-year-old Kelly's big break in the US, but it's not the first time she has picked herself up and dusted herself down after some bad luck.
She recently opened up about her brief spell on Britain's Got Talent.
Kelly lasted just six days as a judge on the popular ITV talent show before Simon Cowell sacked her.
At the time, she kept a dignified silence, but last week described Simon as "disrespectful".
Kelly was hired as a fourth judge alongside Simon, Amanda Holden and Piers Morgan in 2009 but was dropped less than a week later.
Somehow, we don't think this is the last we'll see of lovely Kelly!
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