The Queen of Pop was brought out as a guest during Drake's headline slot, appropriately, just as he was performing his track 'Madonna'.
Madge then planted a big one on Drake – but did he like it?!
At first it seems that he did. He even moved his hand up to grab her hair - but Madonna shut him down, placing his hand firmly back down. But as the kiss went on longer it appears Drake was less than happy...
When Madge let go, Drake immediately screwed up his face and wiped his mouth. Not really the sort of reaction we'd want after we'd kissed someone… Oh dear.
And how sad for Madonna - it had been her life ambition to kiss Drake!
She previously told Us Weekly of the Canadian rapper: "The lifelong ambition I still want to fulfill is to go on a dream date with Drake -- and only kiss him."
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Of course, Madonna is no stranger to courting controversy and making headlines thanks to her lips: who remembers that three-way kiss with Britney Spears and Christina Aguilera at the MTV Video Music Awards 2003.