The This Morning presenter has been absent from the Keith Lemon panel show on maternity leave, as she spent time with third child Chester, born in September 2014.
Celebrity chef Gino D'Acampo, who covered for her, will stay on the show.
Confirming her return, she said: "I'm so excited to be back and I cannot wait to see the whole Celebrity Juice gang again. Strangely, I've missed that strawberry blonde man and it's great that Gino is staying too - it's going to be fun!"
Fearne Cotton will also return as team captain.
Holly went on maternity leave in September, with Amanda Holden and Christine Bleakley covering her on This Morning, and Gino stepping in on Celebrity Juice.
She gave birth to son Chester on Monday, 29 September.
Holly and TV producer husband Dan Baldwin are also parents to son Harry and daughter Belle.
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