A statement released on behalf of the couple to People said: "It is with careful consideration and mutual respect that we have decided to end our marriage.
"Our primary concern remains the wellbeing of our children, and we ask with profound gratitude that you respect our family's privacy at this very sensitive time."
Patrick, 49, has three children with makeup artist Jillian: daughter Tallulah, 12, and seven-year-old twins Sullivan and Darby.
According to reports, it was Jillian who filed the divorce papers, citing irreconcilable differences and requesting joint custody of their children.
They initially met at an LA hair salon and married in July 1999.
Reveal is now on Google Plus! Join us here for the latest pictures, fashion and celebrity news!