The human rights lawyer topped the annual list by legendary US broadcaster Barbara Walters, beating the likes of Taylor Swift, Scarlett Johansson and
Introducing Amal, Walters said: "She is suddenly in that stratosphere which is reserved for Jackie O, Princess Di and Kate Middleton. Everything she does, says or wears is officially fascinating."
Amal is a British-based lawyer who became known throughout the world because of her romance with George.
The couple married in Venice this year.
"She is known primarily through her spouse and while we know little about her, we know a great deal about him – and he has fascinated many women, especially me," added Walters.
Barbara Walters' 10 Most Fascinating People has been televised yearly in the US since 1993, bringing together people she deems fascinating across the worlds of entertainment, sport, politics and more.
Other members of this year's list include atress Scarlett Johansson, comedienne Chelsea Handler, How I Met Your Mother's Neil Patrick Harris, Taylor Swift and Game of Thrones author George RR Martin.
Previous lists have included Kim Kardashian, Miley Crus, Kate Middleton, Honey Boo Boo and Jennifer Lawrence.
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