During Sunday night's results show, Mel chose to save Stereo Kicks instead of Cheryl's act Lauren Platt. And, not happy with Mel's decision, it was then reported that the 'Crazy Stupid Love' singer was livid with her fellow judge after the show- despite Lauren making it through to the semi-final.
But, insisting everything is well and good between the new BFFs, Dermot told the Daily Express Online, Mel and Cheryl are absolutely fine.
When asked if Cheryl had fallen out with Mel, Dermot replied: "God no!"
"When people are honest, it's the most important thing. The important rule is you leave [the arguments] after the show," he added.
Claiming that there was no issue between the girls, the TV presenter even went onto praise them for supporting each other on the show.
He said: "Isn't it wonderful to see two girls working together?"
Dermot's comments come after Cheryl criticised Mel's decision to send X Factor hopeful Lauren home live on air.
After hearing Mel vote to save Louis Walsh's boyband Stereo Kicks, Cheryl said: "I find it amazing that the critiques have been a certain way over the last few weeks, then it comes to this part and it changes, that amazes me."
Luckily for Cheryl, Simon decided to send the vote to deadlock and Lauren was sent through to the semi-finals after it was revealed Stereo Kicks had received the fewest public votes.
But, sparking a feud of his own, Simon has put himself in Louis' bad books as the Irish music mogul has since said he "will never let Simon forget" that his decision sent the boys home.
Meanwhile, Lauren joins Simon's final two acts Fleur East and Ben Haenow, as well as Mel's remaining boy Andrea Faustini in The X Factor semi-finals on Saturday night.
The X Factor continues this Saturday 6 December at 8pm on ITV.
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