Singing 'Brave', the 20-strong group of kids were all made up of cancer survivors, proving just how vital it is to raise dosh to treat the disease.
Looking stunning in a glittery dress, Nicole made sure that each child had their moment of fame by passing the mic around throughout the tune. Aw!
And after the inspirational and rather emotional show, the pretty pop star and cute kids all got together to grab a photo with presenter Davina McCall.
Other celebs who appeared on the Channel 4 show included Kate Moss, David Beckham and Benedict Cumberbatch.
So far, they've raised a whopping £14million for research into curing cancer - and the figure is rising!
Stand Up To Cancer is a joint national fundraising campaign from Cancer Research UK and Channel 4, which funds ground breaking research to bring new and kinder treatments to patients to beat cancer sooner. Click here for more info.
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