Cheryl first had to wave goodbye to Stephanie Nala, after she received the fewest public votes following her performance on Saturday night.
Jazz singer Chloe-Jasmine Whichello then found herself in the sing-off with boy band Stereo Kicks, and Simon Cowell, Louis Walsh and Mel all voted to send her home.
Like Louis, Cheryl now only has two acts remaining in this year's competition, whereas Simon and Mel still have all of their contestants.
Keeping her spirits up, former Girls Aloud star Cheryl has taken to Twitter and thanked those who had taken the time to vote for her girls.
She said: "Want to say thank to everyone that supported and voted for the girls to this point.. It was v much appreciated by us all, thank you #xf."
Cheryl then added: "@CHLOEJASMINEW @StephanieNala Thank you so much for being an absolute pleasure and sweethearts to work with. Love you both."
Cheryl has also thanked pop star Jessie J, who performed her latest track 'Bang Bang' on last night's X Factor results show.
Alongside a photo of herself and Jessie, the Geordie star added: "Thank you @isthatjessiej for bringing your 'BANGING' self onto our show .. #banging #xf."
Meanwhile, Mel B has also told viewers that she felt particularly worried about seeing at least one of her boys leave this weekend.
"I was sooooo worried tonight," Mel Instagrammed. "Thank you everyone for voting for my boys @paulakister @andrea_faustini @jackwaltonofficial @jakequickenden14, we need these boys."
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