The girls - Leigh-Anne Pinnock, Perrie Edwards, Jesy Nelson and Jade Thirlwall - were pictured arriving at Haneda airport in Tokyo.
Ahead of their flght, they wrote on Twitter: "Next stop JAPAN! Expect lots of love, laughs & Little Mix FUN. A BIG hello to all the #JapaneseMixers!"
Leigh-Anne, who showed off her new braided hairdo, looked sporty in a white crop top teamed with grey floral print trousers and Timberland boots. Jade continued the white theme sporting a stunning crop top and trousers - very chic indeed!
Perrie, who is engaged to One Direction star Zayn Malik, wore a pretty crop top teamed with a flowing pink skirt.
Meanwhile, Jesy kept it simple in a black dress teamed with biker boots and a leather jacket.
Taking to Instagram, Jesy later joked: "Sooo defo didn't get the memo about the colour scheme......cheers girls :| #randomontheend #gothgirl #lonerlarry."
Don't worry Jesy, we think you still looked fab!
We did wonder just how many items the girls packed though... In a video posted to Instagram, Little Mix show off bags upon bags of luggage, joking that one suitcase alone includes make-up, while the other is just filled with hair extensions!
Little MIx, who rose to fame after winning series eight of The X Factor in 2011, have been hard at work on their third studio album.
Last month, Little Mix apologised to fans after announcing plans to put their first US headline tour on hold to focus on the album.
The girls will be performing at Japan's Summer Sonic Festival on Saturday (16 August).
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Watch Little Mix's video for 'Salute' below: