Actress and TV host Adrienne has upset the close-knit Kardashian clan because of a recent interview she gave in which she discussed Rob's cheating, saying people are still upset with her for "ruining his life" even though he was the one who was unfaithful.
She also claimed being associated with the Kardashians harmed her career.
Responding via Twitter, Khloe said: "Thought her and I were cool SMH [aka shaking my head]."
She added: "Don't kick my brother while he's down."
Khloe also retweeted Kim's earlier comments, which read: "Funny how she says being with a Kardashian hurt her career yet the only reason she has this article is bc she is talking about a Kardashian.
"So sad when people try to kick my brother when he is down #FamilyForever."
Cheetah Girls star Adrienne and Rob broke up six years. Their romance had been featured on Keeping Up With The Kardashians.
Adrienne's comments to Latina magazine came as reports continue to swirl that Rob is facing issues in his private life. His mum Kris Jenner has admitted he is struggling with some stuff right now, while viewers of Keeping Up saw him refusing to join his family in Thailand in a recent episode.
In May, eyebrows were raised when he flew home from Europe rather than attend Kim's wedding to Kanye West, while his weight gain has also been the subject of many headlines.
While Kim and Khloe have both reacted to Adrienne's interview, Rob has remained silent.
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