The feisty reality star spoke out on Twitter after her younger brother Rob was targeted following photographs showing himself sporting a fuller figure than normal.
His appearance at Los Angeles International Airport with mum Kris Jenner at the weekend caused him to become a trending topic on Twitter.
After declaring her love for Rob, an angry Khloe blasted: "Some of you people are disgusting for calling others names and picking on them. You should be ashamed of yourselves.
"Your words are cutting deeper than you know and are possibly leaving lifetime scars! What shallow souls some of you are. It's sickening to critique anyone off of their appearance. Grow up!"
Rob has been keeping a low profile over recent months, but when he has been photographed, his recent weight gain has been noted.
His decision to shy away from the limelight has prompted rumours he's enrolled in 'fat camps' in a bid to shed the excess pounds but, today, he spoke out to deny that.
"To the blogs saying i went to fat camp or rehab LOL then why am i still fat u fools?? y'all must have run out of real news," he wrote.
"First, i don't believe in rehab or therapy or anything of that sort and second I'm a grown man and will work on myself when i choose. I'm aware that I'm fat that def aint a surprise to me lol and my only therapy will be in the gym anyways had to say somethingggggggggg."
Rob and Khloe are both en route to Paris, France for sister Kim Kardashian's wedding to rapper Kanye West at the weekend.
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