The chart-topping girl band, made up of Leigh-Anne Pinnock, Perrie Edwards, Jesy Nelson and Jade Thirlwall, will hit the road across the pond this September and October.
Little Mix, who won series eight of The X Factor in 2011, have achieved record-breaking success in the States since signing a US record deal with Columbia Records in 2012.
As part of their US tour, the girls will perform 16 shows across North America in support of their latest album, Salute.
The tour will kick off in Boca Raton, Florida, on 10 September and will wrap up on 11 October in Toronto, Canada.
An excited Jade tweeted last night (21 April): "So glad the #SaluteTourUSA is out there, couldn't hold it in any longer! #dreamcometrue thanks to our mixers for making it possible!"
It's set to be a busy month for the girls, who are also heading on the road for a UK arena tour next month, which will kick off on 16 May in Birmingham.
Little Mix, who recently supported Demi Lovato on the North American leg of her 'Neon Lights tour', made chart history last year by achieving the best-selling debut album by a British girl group in the States. The record was previously held by 90s pop group the Spice Girls.
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Watch Little Mix's video for 'Word Up' below: