The singer, 36, took to Twitter on Saturday (12 April) to publicly back his troubled friend.
Celebrity Big Brother star Lee was arrested on Friday for alleged drink driving and suspected drug possession.
And, just hours after the news broke, Simon posted a message directly to his friend on Twitter.
He wrote: "On the outside you see one thing but deep down your sinking! @LeeRyanMusic WE WILL GET THROUGH THIS OUR FANS KNOW YOU! Stay strong brother."
Fellow Blue member Antony Costa retweeted the message.
After Simon posted the message, fans responded with their own words of support.
One wrote: "We'll always be here for him! All that he needs right now is our support, not haters' judgment. #StayStrongLee."
While another loyal fan tweeted: "Love the boy to bits! Mistakes & everything! Dont agree with his ways sometimes, but his music is somethin else x."
On the outside you see one thing but deep down your sinking! @LeeRyanMusic WE WILL GET THROUGH THIS OUR FANS KNOW YOU! Stay strong brother— Simon Webbe (@simonwebbe1) April 12, 2014
Lee spent Friday morning at a police station after being pulled over by police who saw him driving dangerously in London in the early hours of the morning.
The singer's official spokesperson released a statement saying: "I can confirm that Lee was arrested in the early hours of Friday morning. He was arrested on suspicion of drink driving and is awaiting a court date.
"He was charged with failure to provide a specimen and criminal damage. A controlled substance was found in his possession.
"This low point has caused considerable concern to Lee's family, loved ones, and of course the Blue boys... No excuses will be made on Lee's behalf, but he will be seeking professional help for those issues that he has been unable to overcome on his own."
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Watch the video to Blue's 'All Rise' below: