Kelly and brother Jack starred in the US reality show with their famous parents, Sharon and rocker husband Ozzy Osbourne, from 2002 to 2005.
The groundbreaking show focused around the life of Ozzy and the family's daily antics, struggles and triumphs in southern California. The show was an instant hit and aired for four seasons on MTV.
Taking to Twitter last night (5 March), Kelly said: "To this day, it's been 12 years since the first episode of The Osbournes first aired!! WHAT A RIDE IT'S BEEN! Look at us THEN and NOW! thank you for all the love and support through the years xoxo."
Last October, Jack, who is a proud parent to daughter Pearl with wife Lisa Stelly, hinted that his famous clan had discussed the possibility of returning to the TV screen with The Osbournes someday.
Speaking on Access Hollywood Live (24 October), Jack explained that his family have "talked about" a possible return.
"It's been thrown around a little bit," he said. "It's just a different vibe. We don't all live together anymore, we all kind of have our own things going on. So it's a different dynamic."
While the Osbourne family embraced the limelight, Sharon and Ozzy's daughter Aimee chose not to appear on the show and still maintains a low public profile today.
In the years since the show ended, we've seen each Osbourne member continue in their path in the spotlight. While Ozzy continues to make music with band Black Sabbath, Sharon appeared as judge on The X Factor UK last year and is also co-host on US chat show, The Talk.
Aside from getting married and being a first-time dad, Jack hosted his own adventure show Adrenaline Junkie and last year appeared on celebrity dance show, Dancing With The Stars.
Elsewhere, Kelly has had a string of presenting gigs and is now currently co-host of E!'s popular Fashion Police. Kelly also recently lent her vocals to Pharrell Williams' GIRL album for the track 'Marilyn Monroe'.
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