The Big Bang Theory star chose an all-black outfit for the event in Los Angeles, which hung loosely off her trim figure and exposed her back, and she also styled her hair up in a topknot.
To liven up her ensemble, Kaley added a couple of long necklaces and a cow print clutch bag.
Meanwhile, her new hubby and tennis player Ryan opted for a very low-key outfit of faded black jeans, a navy blue T-shirt and black shoes.
The twosome appeared a lot more laid-back at the pre-Grammy bash than they did at a Golden Globe Awards after-party last week, where were pictured in their finest threads.
However, on both occasions it was clear to see how totally loved-up the newlyweds are.
Kaley and Ryan married in a fire and ice themed wedding on New Year's Eve, after announcing their engagement last September.
The couple have been inseparable since they began dating and took a romantic trip to the Bahamas before tying the knot, shunning the idea of waiting until after the wedding for a honeymoon!
And Kaley, 28, is clearly settling into married life with her hubby already, as she tweeted recently: "You know it's an awesome night when you're in your pjs on the couch watching tv with your man and pups by 7:00pm. Goodnight award season!!!"
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