Sam's face was said to have suddenly swollen up during the weekend without warning and she rushed straight to the Diary Room for help.
The TOWIE star was assessed by medics and, as the swelling was beginning to subside, it was reportedly decided that she could be treated onsite with antihistamines.
A big square plaster was stuck on her cheek and she was monitored before eventually being allowed back into the CBB house.
A source told the Daily Star that Sam's mystery illness made her look like "an alien".
"The poor girl looked like something from a horror movie, like an alien," the insider said.
A spokesman for CBB told Reveal: "[Sam] was treated over the weekend in the Diary Room for a medical issue of a personal nature.
"After treatment she was free to leave the Diary Room and join the other housemates."
Last night, viewers watched as the latest nomination results were revealed. Sam looked extremely miffed that she is up for eviction alongside Jim Davidson and Liz Jones.
Sam wasn't the only furious celebrity either, as her sister and fellow TOWIE star Billie also took to Twitter to vent her anger.
Do you think the public will save Sam? Tell us below, as the best comment from across the website each week wins £50.
CBB 2014 lineup:
Copyright: Channel 5