Chris has stepped down from the role of host after 15 years and, using his catchphrase from the programme, said: "It's time to take a break."
The future of the ITV1 quiz show now hangs in the balance and it appears bosses have not lined up anyone else take over from Chris.
In a statement, Chris said: "It's been a huge part of my life for fifteen years and I've loved every minute of it, but it is time for me to move on from Who Wants to Be a Millionaire?.
"It's been the most remarkable journey and I consider myself very fortunate to have been associated with Millionaire? from its inception."
Chris, 67, also referenced the dozens of celebrities who have taken part in special episodes of the show and donated their winnings to charity.
"The calibre of the celebrities like Sir Paul McCartney, George Michael, Sir Alex Ferguson, Simon Cowell, Sir Tim Rice, Sir Terry Wogan, Jonathan Ross, Davina McCall, Stephen Fry, Matt Lucas, etc, is just one indication of how much this show has touched a nerve with everybody," he continued.
"But of course so much more rewarding for all of us has been, not just the celebrities or even the million-pound winners, but all of the ordinary men and women whose lives have been changed - sometimes forever - by being on the show.
"I've worked ridiculously hard these last few years and to quote myself, 'it's time to take a break'."
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