The 29-year-old was pictured partying at Tru Hollywood nightclub on Monday (23 September) alongside the famous rapper and looked happy to let her hair down amid rumours that she and husband Lamar are currently leading separate lives.
Dressed in a smart-casual look for her evening out, Khloe wore a white jacket and light-coloured jeans and kept her long blondish-brown hair down in a simple style.
The Game (real name Jayceon Taylor) donned an eye-catching, bandana printed shirt and teamed it with a black cap, while BFF Malika opted for a sheer black top and dark jeans.
Joined by another friend, the trio posed for a cute picture in the club, which The Game then uploaded to Instagram along with the caption: "Positive energy. Positive people. @khloekardashian @lost_the_love_of_my_life & the coolest twin @theeforevermalika in the club enjoying life. #TheRobinHoodProject"
Another snap of the three friends was then posted on the social network by a local DJ and showed The Game stood with his arm around both girls.
Earlier this year, Khloe was rumoured to have been growing a little too close to the Californian rapper after she was seen joining him on a hike up Runyon Canyon with her brother Rob.
However, these reports were quickly dismissed.
The Game explained that he and Khloe were nothing more than friends and the pair were simply working out together as part of his 60 Days Of Fitness weight loss programme.
And it looks like the two stars have remained pals even after their work out sessions.
Khloe has been surrounding herself with her nearest and dearest at the moment, since her marriage to basketball player Lamar Odom has hit a rocky patch.
The couple are currently said to be living separate lives after rumours emerged of Lamar cheating on Khloe with more than one woman and further allegations that he is battling an addiction to drugs. Reps for the couple have not commented on any of the allegations.
The athlete has been keeping a low profile during this tough time, but yesterday (24 September) he broke his silence by explaining that Khloe and the Kardashian family have been a huge support to him.
He wrote: "They are the ONLY ones that have been here consistently for me during this dark time."
Khloe and Lamar are due to celebrate their fourth wedding anniversary on 27 September.