The 32-year-old Keeping Up With The Kardashians star is set to lend her voice to the hit animated show, playing an alien who has crash-landed in the fictional town of Langley Falls.
Kim's character will play a love interest for extra-terrestrial alien Roger who lives with the Smith family, reports Entertainment Weekly.
This will be one of Kim's first work projects since she welcomed her baby daughter North with rapper boyfriend Kanye West in June.
But Kim isn't the only star set to appear on the cartoon for the new season. US superstar Mariah Carey and actresses Zooey Deschanel and Olivia Wilde are also set to make cameo appearances.
Kim's episode is set to feature later on during season nine of the cartoon series, when it returns on US screens on 29 September. This will also be the last time we'll see the show on Fox, as it is set to move to TBS in 2014.
For viewers in the UK, season nine of American Dad will air on BBC Three later next year.
Kim's not alone: more celebrities who welcomed babies in 2013 in pictures:
Copyright: Love & Lust London