The US television host is enjoying a successful career working for entertainment show Extra, and has bagged a handful of other presenting gigs this year, including a co-host role on Kris Jenner's talk show, his own radio show and a contract as the host of US X Factor.
But this hectic work schedule could be catching up with him, as he revealed yesterday (22 September) that he was ending his evening having been at the Emmy Awards with an IV drip attached to his arm.
Mario, 39, tweeted: "Tough day. Ending it by being hooked up to IV...."
The snap shows the former Saved By The Bell star lying in bed with his daughter Gia and an IV drip with yellow liquid in it placed by the bedside table.
It is unclear as to why Mario needed the drip, since he failed to explain the reason to his concerned followers.
However, he did go on to tweet that he was getting ready to watch an episode of American drama series, Boardwalk Empire, which hints that perhaps he was just feeling a little run down and the drip was his way of combatting the exhaustion.
Earlier in the evening, Mario had been on the red carpet at the Emmy Awards, reporting for Extra and rubbing shoulders with the likes of Sofia Vergara, Claire Danes and Kevin Spacey.
He seemed in good spirits throughout the night and kept his fans up to date with his celeb sighting by posting various snaps of himself with the A-listers.
Nevertheless, hours before hitting the award ceremony Mario - who recently welcomed his second child into the world - had revealed that he was already feeling pretty tired.
He tweeted: "Emmy Sunday! Feeling a bit run down & out of it...I'll rally. Let me know what u want me to ask ur favourite stars. I'll be on the red carpet."
We think it's about time he took a few well-earned days off!
What do you think of Mario's red carpet outfit? Let us know below, as the best comment each week wins £50!