Danielle, 29, made the comment in a recent interview and also described Alex as being "hungry for fame", after he sold his wedding ring from his marriage to Katie Price to magazine for a readers' competition.
"I've always thought it was a creep and he makes my skin crawl," she said.
Alex, however, has now hit back at Danielle - who is good friends with his ex-wife Katie.
Taking to Twitter, cage fighter Alex blasted: "So @MissDLloyd u say I'm fame hungry & make ur skin crawl. Thought u were nice when we met, but u mention my name to grab attention? Two-faced!"
Alex, 38, then made reference to Danielle's controversial appearance in the 2007 series of Celebrity Big Brother, in which she, Jade Goody and Jo O'Meara were accused of bullying Bollywood actress Shilpa Shetty.
He continued: @MissDLloyd Wot r u famous for? Seems like ur going back 2 ur old ways. Bullying people. #cbb2007."
Although Danielle has not responded to Alex's tweets, several fans have got involved in the spat.
One tweeted: "Bit harsh there Alex considering most people would say you're only famous for marrying @MissKatiePrice."
Another added: "The countless amount of interviews you've done talking about Katie and Chantelle [Houghton], you fame hungry tw*t. #Hypocrite."
However, one follower said: "Who is she to slate Alex. He is famous in his own right for CBB.... SHE is a nobody."