In the picture, the US pop star has a white face with turquoise eyebrows and eyelids and a darker shade of blue underneath, giving the impression that she is crying.
Lady Gaga also has part red and part white lips and a smear of yellow above the lefthand side of her mouth.
Staring straight at the camera with her eyes wide open, the singer's hair has been hidden underneath a black scarf.
We almost think Gaga looks like a pierrot doll in the snapshot.
Sharing it on Twitter, she said: "Artwork for new single 'Applause' in HQ."
This new picture comes just days after Lady Gaga uploaded a naked picture of herself, also to promote the single.
Gaga, who has been away from the music scene for some time, will perform 'Applause' at the MTV Video Music Awards in New York in August.
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