The Italian tailor left Essex behind to party at popular nightspot Evissa with fashion retailer and businessman Umar Kamani, after dining at footballer Rio Ferdinand's Rosso restaurant.
Mario made a personal appearance at the club night, wearing a fitted print top, jeans and trainers, to help search for the new face of online fashion site PrettyLittleThing.
Mario was also joined by co-star Charlie Sims. Before the night kicked off, Charlie said: "Just boarded virgin's train on route to Manchester with @Mario_Falcone ... I have the feeling this is going to be a very good night."
Mario clearly partied hard, as he tweeted this morning, "I am hanging!"
Mario and Charlie have struck up quite a friendship as of late, and Charlie's girlfriend Ferne McCann has also noticed their bond after tweeting this week: "Sunbathing all day with the lovers @Mario_Falcone @charlessims_ "
But Mario and Charlie are about to have a lads' holiday soon with Joey Essex, after Mario revealed last night: "Soooo @charlessims_ and myself are booked for Ibiza next week for @JoeyEssex_ birthday! Boom!"
We're also wondering if Joey will bump into his ex-fiancé Sam Faiers, who revealed that she would be partying on the same Spanish island with Ferne next week too!
Missing TOWIE? Watch the series nine highlights below! (Warning: contains swearing)