Professional dancer Gleb, 32, was partnered with Countryfile presenter Anita Rani in 2015, however he has today announced his departure due to "family commitments".
In a Twitter statement, Gleb - who is currently appearing on Celebrity Masterchef - said: "I thoroughly enjoyed taking part on the last series of Strictly Come Dancing and especially the way that the UK gave me such a warm welcome, but due to family commitments, I won't be returning to the show for the next series.
"I'll definitely be tuning in though."
A BBC statement read: "Strictly extends its thanks to those who announced at the end of last series that they wouldn't be returning to the show, and to Gleb Savchenko, who has decided that due to family commitments he will not be appearing in the next series."
Fans have been quick to express their sadness on Twitter, while also sending Russian-born Gleb their good wishes. One said: "No @Gleb_Savchenko on #Strictly this year. Good job I love @MasterChefUK Good Luck Gleb!! #IfYouCookAsGoodAsYouLook."
Another viewer added: "Gutted that @Gleb_Savchenko won't be a professional on #strictly this year ☹ Anita & Gleb were my favourites in 2015!"
Meanwhile, three new professionals will be putting the celebrity dancers through their paces this year. World Champion Katya Jones, Ukrainian Champion Oksana Platero and top Spanish dance professional Gorka Marquez have all joined the lineup.