It's a late-night show, in a similar vein to James Corden's show in the United States, and will be packed full of lively, entertaining and irreverent fun.
With well-known faces joining Rylan each night, plus live music, and mischievous after-hours games, it's all done in front of a live studio audience at the Hospital Club in Central London.
It'll be truly topical, covering all the latest news and gossip, and each famous face will be subject to Rylan's hilarious fun and games.
Up Late With Rylan, Channel 5, 11pm
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