Going head-to-head in the notoriously tough quiz are celebs including Ann Widdecombe, Heston Blumenthal, Johnny Vegas, Tony Blackburn, Janet Street Porter, Dr Christian Jessen, and Kate Garraway.
They're battling it out to win the jackpot for charity, but they must nominate each other to answer until only the winner is left standing.
Who's got the guts and the brains to make it through to the end?
Celebrity Fifteen to One, Channel 4, 8pm
Got an iPad or iPhone? Reveal Mag is specially designed to fit!